PubMed Publications

Peer Reviewed Articles

Musch MW, Mamah D, Gawenis LR, Zhang Z, Ellsworth W, Shalowitz D, Efthimiou P,…, Barrett TA. “T-cell activation causes diarrhea by increasing intestinal permeability and downregulating epithelial Na+/K+ATPase” Journal of Clinical Investigation, 2002, 110:1739-1747.

Efthimiou P, Markenson JA. “Role of Biologic Agents in the Treatment of Immune Mediated Inflammatory Diseases”. Southern Medical Journal, 2005, 98(2): 192-204.

Efthimiou P, Paik P, Bielory L. “Diagnosis and Management of Adult Onset Still’s Disease (AOSD)”. Annals of Rheumatic Diseases, 2006; 65: 564-572.

Ramaswami R, Efthimiou P, Gnanasekaran I. “Musculoskeletal Manifestations of Dialysis; an update” Clinical Rheumatology, 2006 Jul;25(4):440-2.

Efthimiou P, Schwartzman S, Kagen L “Possible Role for TNF-Inhibitors in the Treatment of Resistant Dermatomyositis and Polymyositis”. Annals of Rheumatic Diseases, 2006, Sep;65(9):1233-6.

Rosenkranz ME, Agle LM, Efthimiou P, Lehman TJ. “Systemic and localized scleroderma in children: current and future treatment options”. Paediatric Drugs. 2006;8(2):85-97.

Ogden NS, Ward CM, Kontzias A, Wyatt ST, and Efthimiou P. “Adult Onset Still Disease: 20 Clinical Pearls” Journal of Musculoskeletal Medicine, 2006; 23:788-800.

Efthimiou P. “Tumor Necrosis Factor alpha in inflammatory myopathies: pathophysiology and therapeutic implications”. Seminars in Arthritis and Rheumatism, 2006 Dec; 36(3): 168-72.

Efthimiou P and Georgy S.¨Pathophysiology and Management of Adult Onset Still’s Disease”. Seminars in Arthritis and Rheumatism, 2006 Dec; 36(3): 144-52.

Efthimiou P and Sood S. “QuantiFERON TB Gold Test: the New Standard for Screening of Latent Tuberculosis in Patients with Rheumatoid Arthritis?” Annals of Rheumatic Diseases, 2007 Feb; 66(2):276

Blake AD, West FM, Ghafoor S, and Efthimiou P. “Somatostatin Involvement in Rheumatoid Arthritis” Current Rheumatology Reviews, 2007; 3:31-36.

Efthimiou P,Ward MC, Kontzias A, Ogden NS. “Adult Onset Still’s disease: Can New Pathophysiologic Clues Guide Future Targeted Treatments?” Nature Reviews Rheumatology, 2007 Jun; 3(6): 328-335.

Efthimiou P, Kumar S. “Development of Olecranon Bursitis after Treatment with Abatacept in a Patient with Rheumatoid Arthritis” Contemporary Topics in Rheumatoid Arthritis, 2007; 1(3): 6-8.

Efthimiou P “Translating Basic Research Findings into Therapeutic Advances in Rare Rheumatologic Disorders: Lessons Learned from Adult Onset Still’s Disease” Contemporary Topics in Rheumatoid Arthritis, 2007; 1(4): 4-9.

Efthimiou P, Blanco M. “Intravenous Gammaglobulin and Thalidomide may be an Effective Therapeutic Combination in Refractory Scleromyxedema” Seminars in Arthritis and Rheumatism, 2008 Dec;38(3):188-94

Kontzias A and Efthimiou P. “Adult-Onset Still’s Disease : Pathogenesis, Clinical Manifestations and Therapeutic Advances” Drugs, 2008; 68(3):319-337

Efthimiou P, Nasis O, Lehman TJ. “Aortic aneurysm in Takayasu’s arteritis” Journal of Rheumatology, 2007, Nov;34(11):2312.

Yavari N, Platt H, Michel R, Navarro C, and Efthimiou P.” Environmental and Occupational Exposure in Rheumatoid Arthritis” Journal of Musculoskeletal Medicine, 2008; 25:130-136.

Efthimiou P et al. “Autoinflammatory syndromes and infections: pathogenetic and clinical implications”. Clinical Experimental Rheumatology, 2008; Jan-Feb;26(1 Suppl 48):S53-61.

Efthimiou P, Nasis O, Russell LA. “Classic presentation of a rare disease: melorheostosis”. Journal of Rheumatology, 2008 Jun;35(6):1169.

Souayah N, Chodos A, Krivitskaya N, Efthimiou P, Lambert WC, Sharer LR. “Isolated severe vasculitic neuropathy revealing sarcoidosis”. Lancet Neurology. 2008 Aug;7(8):756-60.

Efthimiou P.” Preoperative management of patients with rheumatoid arthritis underdoing elective surgery while being treated with abatacept”. Contemporary Topics in Rheumatoid Arthritis, 2008; 2(4):6-9.

Efthimiou P, Blanco M. “Pathogenesis of Neuropsychiatric Systemic Lupus Erythematosus and Potential Biomarkers” Modern Rheumatology, 2009;19(5):457-68

Kukar M, Petryna O, and Efthimiou P. “Biological targets in the treatment of Rheumatoid arthritis: A Comprehensive review of Current and In-development Biological Disease Modifying Anti-Rheumatic Drugs”, Biologics:Targets &Therapy, 2009:3 443–457
Petryna O and Efthimiou P. “An Unusual Cause of Lower Back Pain”, Journal of Rheumatology, 2009 Nov;36(11):2556

Efthimiou P, Kukar M, Kagen LJ. “Severe Adult Onset Calcinosis in a patient with a history of Juvenile Dermatomyositis”, Journal of Rheumatology, 2010 Jan;37(1):194

Efthimiou P, Petryna O. ”Headache from Cavernous Sinus Thrombosis in Adamantiades-Behcet’s Disease”, Journal of Clinical Rheumatology, 2010; Dec;16(8):409

Efthimiou P, Kukar M. “Complementary and Alternative Medicine: Proposed mechanism of action and efficacy of commonly used modalities in Rheumatoid arthritis, A Comprehensive Review of the Recent Literature”, Rheumatology International; 2010 Mar; 30(5): 571-86

Efthimiou P, Kukar M. “Complementary and Alternative Medicine in Rheumatoid Arthritis: No Longer the Last Resort”, HSS Journal, 2010; 6: 108–111

Petryna O, Yavari N, Efthimiou P. “Occupational and Environmental Exposures in Lupus and Systemic Sclerosis: A preventable Risk Factor?” Journal of Musculoskeletal Medicine, 2010; 27:395-402.

Efthimiou P, Kukar M, Krishnan P. “Posterior Reversible Encephalopathy Syndrome (PRES): a severe manifestation of neuropsychiatric systemic lupus erythematosus (NPSLE)” Arthritis and Rheumatism, 2010 Jun;62(6):1692.

Efthimiou P, Petryna O, Kukar M, Gold M.” Characteristic neuroimaging findings in posterior reversible encephalopathy syndrome (PRES) in SLE: Reply.” Arthritis and Rheumatism, 2011 Jan; 63(1):309-10

Efthimiou P, Kukar, Hersh A. “Rituximab and Lupus Interstitial Lung Disease: Friend or Foe?” International Journal of Rheumatic Diseases, 2011 Feb; 14(1): e3-4.

Efthimiou P, Pokharna H, Kukar M, Hennessey K. “PCP Chemoprophylaxis is Essential for Lymphopenic Dermatomyositis Patients Treated with Immunomodulators”, Muscle & Nerve, 2011 Jun; 43 (6):918-9.

Efthimiou P, Kukar M. “Lupus Pernio: Sarcoid-specific Cutaneous Manifestation Associated with Chronic Sarcoid Arthropathy”, Journal of Clinical Rheumatology, 2011; 17 (6): 343.

Mehta B and Efthimiou P. “Latent Tuberculosis in RA: The Disease and the Diagnosis”, Journal of Musculoskeletal Medicine, 2011; 28 (7): 249-55

Mehta B and Efthimiou P. “Latent Tuberculosis in RA: Current Diagnostic Techniques and Treatment”, Journal of Musculoskeletal Medicine, 2011; 28 (8): 300-307

Mehta B, Mueller W, and Efthimiou P. “CNS vasculitis: A protean manifestation of HIV/AIDS”, Journal of Musculoskeletal Medicine, 2011; 28 (12): 462-464

Mehta B and Efthimiou P. “Radiographic Improvement in Sarcoid Arthropathy after Infliximab Treatment”, Journal of Rheumatology, 2012; 39;664-5

Kukar M and Efthimiou P. “Therapeutic Armamentarium against Rheumatoid Arthritis in the New Decade: not there yet, but getting closer”, European Musculoskeletal Review;, May, 2012

Mehta B and Efthimiou P. “Ferritin in Adult onset Still’s disease (AOSD): just a useful innocent bystander?” International Journal of Inflammation, 2012; 2012:298405. Epub Mar 25

Kontzias A and Efthimiou P. “”The Use of Canakinumab, a Novel IL-1β Long Acting Inhibitor, in Refractory Adult-onset Still’s Disease.” Seminars in Arthritis and Rheumatism, 2012 Oct; 42(2):201-5.

Petryna O, Cush JJ, and Efthimiou P. “IL-1 Trap Rilonacept in Refractory Adult-onset Still’s Disease”, Annals of Rheumatic Diseases, 2012; 71: 2056-2058

Efthimiou P, Moorthy N, Mavragani CP, Skokos D, Fautrel B “Editorial: Adult- onset Still’s Disease and Autoinflammation” International Journal of Inflammation, 2012:964751. Epub 2012 Aug 29

Hsieh J, Kadavath S, and Efthimiou P. “Can Traumatic Injury Trigger Psoriatic Arthritis?” Clinical Rheumatology, 2014, Epub ahead of print

Kadavath S and Efthimiou P. “Canakinumab in Autoimmune and Autoinflammatory Rheumatic Diseases.” Expert Opinion on Orphan Drugs, Jan 2014, Vol. 2,1, pp 27-35.

Efthimiou P, Kadavath S, Mehta B.”Life-threatening complications of adult-onset Still’s disease. Clinical Rheumatology. 2014 Mar;33(3):305-14.

Kadavath S, Zapantis E, and Efthimiou P. “A Novel Therapeutic Approach In Adult Onset Still`s Disease- Associated Pulmonary Hypertension: Targeting Interleukin 6” International Journal of Rheumatic Diseases, 2014, International Journal of Rheumatic Diseases. 2014 Mar;17(3):336-40.

Kadavath S and Efthimiou P.”Adult-onset Still’s disease-pathogenesis, clinical manifestations, and new treatment options” Annals of Medicine. 2015 Jan 22:1-9.

Kadavath S, Bobic S, Efthimiou P. “Use of B lymphocyte stimulator inhibitor belimumab may be associated with a decrease in the serum concentration of epidermal growth factor in patients with primary Sjögren’s syndrome.” Clinical Rheumatology. 2015;34(9):1651-1652.

Afzal A, Chittalai S,Wong I, Efthimiou P. “Unmasking IgG4-related autoimmune pancreatitis from pancreatic cancer: A lesson learned” Int J Case Rep Images. 2016;7(2):123–126.

Ruiz-Irizarry Y and Efthimiou P. “Rhabdomyolysis and Polyarticular Inflammatory Arthritis May be the Initial Presentation of Chronic Myelogenous Leukemia (CML)”. J Rheum Dis Treat. 2015, 1:3

Efthimiou P, Yadlapati S. “Impact of IL-1 inhibition on fatigue associated with Autoinflammatory syndromes” Modern Rheumatology. 2016; Jan;26(1):3-8.

Mehta B, Zapantis E, Petryna O, Efthimiou P “Screening Optimization of Latent Tuberculosis Infection in Rheumatoid Arthritis Patients”.  Arthritis, 2015;2015:569620.

Yadlapati S, Efthimiou P. “Inadequate response or intolerability to oral methotrexate: Is it optimal to switch to subcutaneous methotrexate prior to considering therapy with biologics?” Rheumatology International. 2016 May;36(5):627-33.

Yadlapati S, Efthimiou P. “Autoimmune/Inflammatory Arthritis Associated Lymphomas: Who Is at Risk?”. BioMed Research International, 2016; 2016: 8631061.

Books, Monographs and Chapters

Efthimiou P and Paget SA. “Rheumatoid Arthritis”. Chapter in: Hospital Healthcare Europe 2003/2004, P38-39, Healthcare Publications, 2003, Campden Publishing, London, UK

Schwartzman S and Efthimiou P. “Progressive Systemic Sclerosis (PSS) and Related Disorders”. Chapter in: American College of Physicians (ACP) Expert Guide to Rheumatology, 2005, pp135-147, ACP Publications, Philadelphia, PA.

Efthimiou P and Kagen L. “Polymyositis, Dermatomyositis, and Inclusion Body Myositis”. Chapter in: Manual of Rheumatology and Outpatient Orthopedic Disorders: Diagnosis and Therapy, Fifth Edition, 2005, pp 245-252, Lippincott, Williams & Wilkins, New York, NY

Efthimiou P and Markenson J. “Psoriatic Arthritis”. Chapter in: Manual of Rheumatology and Outpatient Orthopedic Disorders: Diagnosis and Therapy, Fifth Edition, 2005, pp 318-24, Lippincott Williams & Wilkins, New York, NY

Efthimiou P. “Rheumatology”. Chapter in: Last Minute: Internal Medicine, Miksad, R. Meyer, K. and Delamora, P. McGraw-Hill. NY, NY 2008

Efthimiou P, Petryna O, Kukar M. “Complex situations in patients with adult-onset Still disease” in Autoimmune Diseases: Complex and Acute Situations, 2011, pp 221-232, Springer, NY, NY.

Efthimiou P, Kontzias A. “Adult-onset Still’s Disease” chapter in: Internal Medicine Specialty Board Review, Editor-in-Chief: R.R. Baliga, 2014, McGraw Hill, in press.

Efthimiou P, Kontzias A. “Treatment of Rheumatoid Arthritis” chapter in: Encyclopedia of Medical Immunology, Eds: Ian R.Mackay, Noel R. Rose, Springer, NY, NY, 2014.


Efthimiou P and Barrett TA.
“Lamina Propria T-Cell Activation Induces Diarrhea Through A TNF-a Mediated
Down-regulation of Small Bowel Na+/K+ ATPase”, Poster Finalist, National
Associates Research Competition, ACP Annual Session, 2001, Atlanta, GA

Erkan D, Efthimiou P, Sammaritano L, Lockshin MD. “Antiphospholipid Antibody
(aPL) – Related Transient Ischemic Attacks (TIA): What is the Optimal Management?” Poster Presentation. Arthritis & Rheumatism, 2002; 46:9 (Suppl); S47

Efthimiou P, Harrison MJ, MacKenzie CR, Paget SA. “Complementary and Alternative Medicine in Rheumatoid Arthritis: No Longer the Last Resort”. Poster Presentation , Arthritis & Rheumatism, 2002; 46:9 (Suppl); S342

Efthimiou P, Rosenkranz ME, Mackenzie R, Adler R, Paget SA. “IVIG and Thalidomide Combination is an Effective Novel Therapy for Scleromyxedema”. Poster Presentation, Arthritis & Rheumatism 2003; 48:9 (Suppl); S617

Rosenkranz ME, Agle L, Efthimiou P, Onel KB, Lehman T JA.
“Is Routine Testing of Anti-Topoisomerase Antibody (Scl-70) and Anti-
Centromere Antibody (ACA) Warranted in a Pediatric Population?” Poster
Presentation, Arthritis & Rheumatism, 2003; 48:9 (Supplement);S513

Ramaswamy D, Gnanasekaran I, Nikolov N, Efthimiou P, Gour N, Paget SA.
“Musculoskeletal manifestations in patients on hemodialysis for endstage renal
Disease (ESRD): A profound change in character and incidence associated with
advancements in dialysis therapy”. Poster Presentation, Arthritis & Rheumatism
2003; 48:9 (Suppl); S533

Efthimiou P, Ivashkiv LB. “Increased FcγRI Expression in IFN-γ Primed Human
Macrophages Enhances TNF-α Production after FcγReceptor (FcγR) Crosslinking”, Poster Presentation. Arthritis & Rheumatism, 2003; 48:12 (Suppl); SY9:3621

Efthimiou P, Schwartzman S, Kagen L. “Is There a Role For Anti-TNF Therapy in Dermatomyositis and Polymyositis?” Podium presentation, 2004 EULAR, Berlin, Germany. Annals of the Rheumatic Diseases, 63: 67-67 Suppl. 1 Jul 2004.

Efthimiou P, Rosenkranz ME, Lehman TJ. “Does Etanercept Have A Role In The Treatment Of Juvenile Dermatomyositis?” Annals of the Rheumatic Diseases, 2005; 64(Suppl III):573.

Efthimiou P, Rosenkranz ME, Hays A, Kagen LJ. “Etanercept: A Novel Treatment Of Dysferlinopathy And Limb-Girdle Muscular Dystrophy Type 2b”
Annals of the Rheumatic Diseases, 2005; 64(Suppl III):575.

West FM, Blake AD, Efthimiou P. “Somatostatin Regulates the TNF-alpha Stimulated Extracellular Regulated Kinase Cascade of Human Rheumatoid Arthritis Synoviocytes” Arthritis & Rheumatism, 2006; 54:9 (Suppl); S218

Hersh AB, Efthimiou P. “Rituximab in Lupus Pneumonitis: Breath Easier”. Journal of Allergy & Clinical Immunology, 2007; 119:1 (Suppl); S260

Sood S, Sharma R, Efthimiou P. “Quantiferon TB-Gold Testing and Rheumatoid Arthritis?” Annals of the Rheumatic Diseases, 2007; 66(Suppl 1):A60

Sharma R, Hersh AB, Efthimiou P. “Rituximab Use in Lupus Pneumonitis” Annals of the Rheumatic Diseases, 2007;66(Suppl 1):A58

Paralejo BM, Aquino M, Efthimiou P. “Increased Levels of IL-6 and Ferritin as Potential Biomarkers in Adult onset Still’s DIsease”. Annals of Allergy Asthma& Immunology, 2008; 100:1 (Suppl); A59-60

Aquino M, Efthimiou P. “Corneal Ulceration as the Initial Manifestation of Underlying Cryoglobulinemia”. Annals of Allergy Asthma& Immunology, 2008; 100:1 (Suppl); A58

Petryna O, Hooda A, Mankotia N, Efthimiou P. “Adult onset Still’s Disease Presenting with a Symmetric Linear Cutaneous Eruption of the Lower Extremities and Macrophage Activation Syndrome”. Poster presentation, ACP Downtown Regional Meeting, ACP Associate Poster Competition; 2009, NY, NY

Petryna O, Efthimiou P. “Rilonacept Treatment of Refractory Adult Onset Still’s Disease”. Poster presentation, American College of Rheumatology, 73rd Annual Scientific Meeting; 2009, Philadelphia, PA

Petryna O, Kontzias A, Kirou K, Efthimiou P “Hyperferritenemia in Adult honest Still’s Disease is Independent of Plasma Type I Interferon Activity”. Poster presentation, EULAR 2010 Scientific Meeting; June 16-19, 2010, Rome, Italy

Petryna O, Cush J, Kontzias A, Efthimiou P “Successful use of of the IL-1 trap Rilonacept in AOSD refractory to Anakinra” Poster presentation featured in EULAR Poster Tour, EULAR 2011 Scientific Meeting; May 25-29, 2011, London, UK

Mehta B, Sohn B, and Efthimiou P “Combining Tuberculin Skin Test and Interferon Gamma Release Assays for Latent Tuberculosis Infection Screening May Be Necessary for the Exclusion of Latent Tuberculosis in a High Risk Individuals with RA” Arthritis & Rheumatism, 2011; 63:10 (Supplement);S463-4, Poster presentation featured in ACR Poster Tour, American College of Rheumatology, 75th Annual Scientific Meeting; 2011, Chicago, IL

Efthimiou P, Petryna O,Mehta B, Kontzias A, Cush JJ “Successful use of Canakinumab in AOSD refractory to Short Acting IL-1 Inhibitors” Poster presentation, EULAR 2012 Scientific Meeting; June 6-9, 2012, Berlin, Germany

Mehta B, Zapantis E, Efthimiou P “A Proposed Effective Strategy for the Screening of Latent Tuberculosis Infection in Rheumatoid Arthritis Patients” Poster presentation, EULAR 2012 Scientific Meeting; June 6-9, 2012, Berlin, Germany

Kadavath S, Zapantis E, Mehta B, Efthimiou P “Effectiveness Of Combining Tuberculin Skin Test And Interferon Gamma Release Assays As A Screening Strategy For Detecting Latent Tuberculosis Infection In High Risk Patients With Systemic Lupus Erythematosus”, Poster presentation, EULAR 2013 Scientific Meeting; June 12-15, 2013, Madrid, Spain

Bobic S, Kadavath S, Zapantis E, Efthimiou P “Use Of B Lymphocyte Stimulator (Blys) Inhibitor Belimumab May Be Associated With Decreased Multiple Serum Biomarkers In Patients With Primary Sjögren’s Syndrome (pSS)”, Poster presentation, American College of Rheumatology, 77th Annual Scientific Meeting; 2013, San Diego, CA

Mehta B, Efthimiou P et al “Raynaud’s Phenomenon and African American Race Are Independently Associated With Non-Hodgkin’s Lymphoma In Sjogrens Syndrome Patients: Findings From a United States National Study” Poster presentation, American College of Rheumatology, 77th Annual Scientific Meeting; 2013, San Diego, CA

Efthimiou P, Kadavath S, Bhatta A, Charles E, Dustin L “Characterization of Phenotype and Immunoglobulin Genes of Auto-reactive B Cells in Sjogren’s Syndrome” Poster presentation, EULAR 2014 Scientific Meeting; June 11-14, 2014, Paris, France

Kadavath S, Chittalai S,…, Efthimiou P, “14-3-3 ETA Protein : A Novel Biomarker for the Diagnosis of Rheumatoid Arthritis”. Poster presentation, EULAR 2014 Scientific Meeting; June 11-14, 2014, Paris, France


Vasconcellos A, Chittalai S and Efthimiou P “Does 14-3-3 ETA Protein Offer Any Additional Diagnostic Value in Rheumatoid Arthritis?” Poster Presentation, American College of Rheumatology, 79th Annual Scientific Meeting; 2015, San Francisco, CA